Renal Dysplasia
Chiata, 1996, chewing on a great find.
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Renal Dysplasia |
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| Breeding | Color | Genetics | Renal Dysplasia |
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"Chiata ... head high, little one, nose to the wind ... the ancestral home beckons. Chiata has already made a difference, both in life and in death. She was part of the beginning of your long journey as it was redefined by RD. In death, she exemplifies the responsibility of a breeder to ensure the health of future generations ... and that things are not always what they seem. Throw on the mantle of her memory, for it will surely warm you as you continue the path set before you."
Written by Vickie Kuhlmann Renal Dysplasia (RD is a hereditary developmental problem pertaining to the kidney. Canines are born with immature kidneys. By the time the puppy is 8 weeks old, the transition to mature kidneys should be complete. Dogs with RD never complete this transition. A number of other breeds share this problem with the Lhasa Apso. The following articles are great resources for learning more about Renal Dysplasia, including Debby's award-winning series. Note! Some of the information - particularly about VetGen - is outdated. Articles
Breaking The Silence: |
Hip Hip Hoorah!! The results from Dr. Whiteley's Pedigree study of her candidate gene are in. She has the gene and two mutations! According to Dr. Whiteley, "our pedigree study is complete. We have examined the two mutations discovered in our candidate gene in Shih Tzus, and one mutation in common with both Shih Tzus and Lhasa apsos. In 100% of the cases of clinical samples (either biopsied, or by abnormal results on blood and urine tests of kidney function) the individual had either one or the other mutations. In four Shih Tzu litters that were severely affected, the puppies had both mutations. In some cases where the dogs appeared to be normal they also had the mutation(s). The only clear dogs in this study were clear by biopsy. 13 non RD breed dogs were also examined, they they did not have either of the mutations. All of this data taken together indicates a mode of inheritance that is dominant with incomplete penetrance. We are denoting the first mutation as A and the second as B, and are continuing to investigate if mutation B is also in Lhasa apsos, or other breeds. These results are in absolute agreement of a 10 year study conducted at University of Pennsylvania by Dr. Kenneth Bovee. His findings also showed a mode of inheritance that is consistent with dominant with incomplete penetrance. The results are likewise consistent with the wide range of clinical manifestations and the sudden appearance of the disease from apparently normal parents." The results are also in agreement with a Study of Renal Dysplasia done by Dr. Catherine Marley, using biopsy results of the Fleetfire Timbers' dogs. In the latest issue of the American Kennel Club Gazette, the contribution of Debby's RD database is recognized in This Miserable Thing.
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